Airline Rewards

[florida4sun]

Hi,
I know some folks on herevery are very knowledgable with airmiles/rewards. I am now flying around quite a bit with multiple UK - USA flights, USA internal flights, the odd longhaul to far The Far East/OZ and various european locations
Generally I look for the best financial rate and not particulary fussed about the airline. What is my best option for collecting miles/rewards?

Thanks

Martin