One quick piece of advice so that you can understand the road signs. The roads will say either North/South or East/West. This can be rather daunting but if you study a map of Florida then you'll know which way to head to.
On our first trip out of Orlando Intl airport we would take the B-line expressway and then the I4. When you're tired it's confusing when you see a sign for Orlando (East) and Tampa (West). Orlando is for the actual town and most holiday homes are in Kissimmee, so you need to take the Tampa (West) turn off.
Now we use the South Access route out of airport and look for the Florida Greenway sign (417 - Disneyworld) much easier and quieter for novice drivers to Florida.