I'd well believe it. It's all recursive in terms of the effects of saving just a tiny bit of weight/fuel. I remember watching a documentary once, I think about the design of the 777. One of the key design goals was minimising the weight of each and every component. Not for the sole purpose of saving that amount of weight but because of the way each gram of weight saved multiplies up over and over again in terms of how much fuel it saves, or costs, operationally.