The First Coast.
Jacksonville-Ponte Vedra-St Augustine.
It's the best kept secret in Florida. If I wasn't working in Orlando thats definately where I'd live.
The beaches are the best in the state. Jax (Jacksonville) has great nightlife. And Jax is the largest city in the USA. St Augustine is the prettiest town in Florida. Also the oldest city in the USA.
Ever since the NFL came to town, The Jacksonville Jaguars, the city has boomed. In the first year the Jags were there over 500 corperations re-located there. It's also one of the last true Southern cities left in Florida.
They even had the Super Bowl there in January. You'll find plenty of opertunities for business investments.

I lived there for 4 years and would dearly love to go back.